醫(yī)師資格證
在線(xiàn)問(wèn)診
預(yù)約掛號(hào)
專(zhuān)業(yè)方向
專(zhuān)業(yè)擅長(zhǎng)
對(duì)口腔顱頜面-頭頸部良性（如頜骨囊腫，鰓裂囊腫，腮腺混合瘤，成釉細(xì)胞瘤等）和惡性腫瘤（舌癌，牙齦癌，頰癌，腭癌，舌根癌等口腔口咽癌和頜面頜骨肉瘤）在分子水平方面有深入的研究。在良惡性腫瘤手術(shù)治療，軟硬組織缺損修復(fù)以及中晚期口腔癌化學(xué)治療、基因靶向治療和免疫治療等綜合治療；口腔頜面部脈管疾病-血管瘤，淋巴管瘤，脈管畸形的基礎(chǔ)研究，治療包括手術(shù)、超選擇性栓塞、放射、硬化、核素和冷凍等綜合治療；口腔頜面部外傷骨折救治；口腔頜面部感染的治療；口腔頜面部先天（唇腭裂和頜骨畸形）后天畸形（外傷疤痕和缺損）整復(fù)；頜骨前突或后縮畸形整復(fù)和口腔顱頜面痛癥和神經(jīng)精神疾病的診斷和治療等有很深造詣。開(kāi)展了內(nèi)窺鏡微創(chuàng)外科技術(shù)，顱底咽旁腫瘤以及侵犯頸動(dòng)脈晚期頭頸腫瘤和頸動(dòng)脈體瘤治療。
個(gè)人簡(jiǎn)介
陳偉良，中山大學(xué)二級(jí)教授，一級(jí)主任醫(yī)師， 博士生導(dǎo)師，國(guó)家重點(diǎn)臨床專(zhuān)科（口腔頜面外科）學(xué)科帶頭人，中山大學(xué)顱頜面外科中心主任，中山大學(xué)孫逸仙紀(jì)念醫(yī)院(附屬第二醫(yī)院)口腔科主任。廣東省醫(yī)學(xué)會(huì)頜面-頭頸外科學(xué)分會(huì)主任委員。國(guó)際口腔頜面外科協(xié)會(huì)會(huì)員和國(guó)際口腔癌協(xié)會(huì)會(huì)員。1983年中山醫(yī)科大學(xué)口腔醫(yī)學(xué)系畢業(yè)，1987年中山醫(yī)科大學(xué)高級(jí)英語(yǔ)班培訓(xùn)，1998年美國(guó)加州大學(xué)（UCLA）客座教授, 在美研修口腔頜面外科，2003年在澳大利亞皇家兒童醫(yī)院研修顱頜面外科，2005年中山大學(xué)嶺南（大學(xué)）學(xué)院高級(jí)工商管理班畢業(yè)，獲h-EMBA學(xué)位。自1983年中山醫(yī)科大學(xué)口腔醫(yī)學(xué)系畢業(yè)以來(lái)一直在中山大學(xué)孫逸仙紀(jì)念醫(yī)院（附屬第二醫(yī)院）口腔頜面外科從事醫(yī)療、教學(xué)和科研工作。1990年晉升為講師，主治醫(yī)師；1995年破格晉升為副主任醫(yī)師，1996年轉(zhuǎn)評(píng)為副教授，碩士研究生導(dǎo)師；2000年晉升教授，主任醫(yī)師。1994年至1997年任口腔科副主任，1997年至2000年任口腔科主任，2001年至2003年任中山大學(xué)顱頜面外科中心副主任兼中山二院南院副院長(zhǎng)。2005年至2007年任中山大學(xué)顱頜面外科中心副主任兼附屬第二醫(yī)院口腔頜面外科主任。2007年竟聘上三級(jí)教授，2008年至今任中山大學(xué)顱頜面外科中心主任兼孫逸仙紀(jì)念醫(yī)院口腔科主任，博士研究生導(dǎo)師。2011年作為口腔頜面外科學(xué)科帶頭人，主持申報(bào)國(guó)家重點(diǎn)臨床專(zhuān)科（口腔頜面外科）獲得成功，并帶領(lǐng)口腔頜面外科團(tuán)隊(duì)開(kāi)展工作。2012年，經(jīng)國(guó)家衛(wèi)計(jì)委嚴(yán)格審定并批準(zhǔn)，主持第三類(lèi)醫(yī)療技術(shù)-口腔頜面部腫瘤顱頜聯(lián)合根治術(shù)和顱頜面畸形矯治術(shù)。2014年竟聘上二級(jí)教授，一級(jí)主任醫(yī)師。 對(duì)口腔顱頜面-頭頸部良性（如頜骨囊腫，鰓裂囊腫，腮腺混合瘤，成釉細(xì)胞瘤等）和惡性腫瘤（舌癌，牙齦癌，頰癌，腭癌，舌根癌等口腔口咽癌和頜面頜骨肉瘤）在分子水平方面作深入的研究。對(duì)良惡性腫瘤手術(shù)治療，軟硬組織缺損修復(fù)以及中晚期口腔癌化學(xué)治療、基因靶向治療和免疫治療等綜合治療；口腔頜面部脈管疾病-血管瘤，淋巴管瘤，脈管畸形的基礎(chǔ)研究。治療包括手術(shù)、超選擇性栓塞、放射、硬化、核素和冷凍等綜合治療；口腔頜面部外傷骨折救治；口腔頜面部感染的治療；口腔頜面部先天（唇腭裂和頜骨畸形）后天畸形（外傷疤痕和缺損）整復(fù)；頜骨前突或后縮畸形整復(fù)和口腔顱頜面痛癥和神經(jīng)精神疾病的診斷和治療等有較深造詣。近年來(lái)，大力開(kāi)展了內(nèi)窺鏡微創(chuàng)治療顱底咽旁腫瘤以及侵犯頸動(dòng)脈晚期頭頸腫瘤和頸動(dòng)脈體瘤治療，取得理想療效。 國(guó)家重點(diǎn)臨床專(zhuān)科（口腔頜面外科）學(xué)科帶頭人，發(fā)表學(xué)術(shù)論文100多篇，其中97篇被SCI收錄，國(guó)際會(huì)議交流14篇?！渡喟└涡g(shù)后病者生存率和生存質(zhì)量評(píng)估》2003年獲廣東省人民政府科技成果三等獎(jiǎng)；《口腔頜面頭頸部大型組織缺損修復(fù)的系列研究》2007年獲廣東省人民政府科技成果二等獎(jiǎng)；2003年（澳大利亞墨爾本）和2005 年（希臘雅典）獲國(guó)際口腔癌協(xié)會(huì)頒發(fā)的優(yōu)秀獎(jiǎng)。2006年5月在意大利舉行的國(guó)際口腔癌會(huì)議上成為學(xué)術(shù)組成員。 《口腔頜面部腫瘤顱頜聯(lián)合根治術(shù)與顱面缺損的修復(fù)與重建》和《侵犯頸動(dòng)脈、顱底復(fù)發(fā)性頭頸惡性腫瘤的挽救性手術(shù)與缺損修復(fù)》分別獲我院2012年 度和2016年度醫(yī)療新技術(shù)二等獎(jiǎng)?！渡喟└涡g(shù)病者預(yù)后的評(píng)估》和《口腔頜面部血管瘤-脈管疾病綜合治療》分別獲得2002年和2014年廣東省人民政府科技成果三等獎(jiǎng)。主持國(guó)家及省部級(jí)科研課題15項(xiàng)，資助金額200多萬(wàn)元。 國(guó)際著名雜志Cancer, Cancer Biomarkers, Head & Neck，International Journal of Oral & Maxillofacial Surgery, Oral Oncology, World Journal of Surgical Oncology，Journal of Oral Pathology and Medicine, European Surgical Research, Clinical Anatomy, Saudi Medical Journal, European Surgical Research, International Journal of Otolaryngology, International Journal of Pediatric Otorhinolaryngology, Journal of Pediatric Surgery，Annals of Medical and Health Sciences Research, Indian Journal of Dental Research, Open Journal of Stomatology和中華醫(yī)學(xué)雜志, Chinese Journal of Dental Research，中山大學(xué)學(xué)報(bào)（醫(yī)科版）和中國(guó)口腔頜面外科雜志等國(guó)內(nèi)外著名雜志的審稿專(zhuān)家，以及2011年版《中文核心期刊要目總覽》評(píng)審專(zhuān)家?，F(xiàn)任中國(guó)口腔頜面外科雜志和中國(guó)實(shí)用口腔科雜志編委。1994年香港國(guó)際唇腭裂會(huì)議作學(xué)術(shù)報(bào)告，2003年澳大利亞墨爾本國(guó)際口腔癌學(xué)術(shù)會(huì)議作學(xué)術(shù)報(bào)告，2005年希臘雅典國(guó)際口腔癌學(xué)術(shù)會(huì)議作學(xué)術(shù)報(bào)告，2005年赴美國(guó)加州大學(xué)伯克利分校、洛杉磯分校和斯坦福大學(xué)調(diào)研醫(yī)藥衛(wèi)生管理及學(xué)術(shù)流，2007年荷蘭阿姆斯特丹第一屆世界口腔腫瘤大會(huì)作學(xué)術(shù)報(bào)告，2009年5月參加上海第19屆國(guó)際口腔頜面外科大會(huì)作學(xué)術(shù)報(bào)告和主持分會(huì)場(chǎng)學(xué)術(shù)活動(dòng)，2009年7月參加在加拿大大多倫多舉行的第二屆世界口腔腫瘤大會(huì)并作學(xué)術(shù)報(bào)告。2003年～2016年主持國(guó)家級(jí)繼續(xù)教育項(xiàng)目—《口腔頜面-頭頸腫瘤預(yù)防和綜合治療高級(jí)研修班》，1998年至2013年指導(dǎo)口腔頜面外科碩士研究生30多名，指導(dǎo)博士后和博士生20多名主持國(guó)家及省部級(jí)科研課題15項(xiàng)，資助金額200多萬(wàn)元。其中包括：：2014年廣東省科技計(jì)劃項(xiàng)目—氧化氮合酶在普萘洛爾治療血管瘤中的作用機(jī)制研究；2011年國(guó)家自然科學(xué)基金課題—iNOS/ NO在癌相關(guān)成纖維細(xì)胞促進(jìn)舌鱗癌侵襲轉(zhuǎn)移中的作用機(jī)制研究；2011年廣東省自然科學(xué)基金課題—癌相關(guān)成纖維細(xì)胞激活一氧化氮合酶信號(hào)促進(jìn)舌鱗癌侵襲轉(zhuǎn)移的作用機(jī)制研究和2011年廣州市科技計(jì)劃項(xiàng)目—葉酸預(yù)防維甲酸誘導(dǎo)的小鼠腭裂的基因表達(dá)譜的的研究。陳偉良近幾年發(fā)表的SCI論文題錄 92. Chen WL, Yang ZH, Huang ZQ, Fan S, Zhang DM, Wang YY. Craniofacial Resection and Reconstruction in Patients With Recurrent Cancer Involving the Craniomaxillofacial Region. J Oral Maxillofac Surg. 2017 Mar;75(3):622-631.91. Chen WL, Fan S, Huang ZQ, Zhang DM. Endoscopy-Assisted Transoral Versus Endoscopy-Assisted Transcervical Minimal Incision Plus Mandibular Osteotomy Approach in Resection of Large Parapharyngeal Space Tumors. J Craniofac Surg. 2017 Feb 6. doi: 10.1097/SCS.0000000000003478. [Epub ahead of print]90. Chen WL, Fan S, Zhang DM. Endoscopically assisted extracapsular dissection of pleomorphic adenoma of the parotid gland through a postauricular sulcus approach in young patients. Br J Oral Maxillofac Surg. 2017 May;55(4):400-403.89．Fan S, Zhang DM, Chen WL. Endoscopy-Assisted Resection of Benign Lesions on the Base of the Tongue via the Transoral Approach Using a Harmonic Scalpel. J Oral Maxillofac Surg. 2017 Mar 14. pii: S0278-2391(17)30255-0. doi: 10.1016/j.joms.2017.03.002. [Epub ahead of print]88.Chen WL, Yang ZH, Huang ZQ, Fan S, Zhang DM, Wang YY. Craniofacial Resection and Reconstruction in Patients With Recurrent Cancer Involving the Craniomaxillofacial Region. J Oral Maxillofac Surg. 2016 Sep 13. pii: S0278-2391(16)30791-1. doi: 10.1016/j.joms.2016.08.044. [Epub ahead of print] 87.Huang ZS, Chen WL, Huang ZQ, Yang ZH. Dysphagia in Tongue Cancer Patients Before and After Surgery. J Oral Maxillofac Surg. 2016;74(10):2067-72.86.Chen WL, Yang ZH, Zhou B, Fan S, Zhang DM, Wang YY. Salvage Surgery for Patients with Recurrent Oral and Oropharyngeal Squamous Cell Carcinoma Involving the Carotid Artery. J Oral Maxillofac Surg. 2016;74(7):1483-93.85. Fan S, Wang YY, Wu DH, Lai DL, Feng YH, Yu X, Lin ZY, Zhang DM, Chen WL, Liang JQ, Li JS. Intraoral lining with the fibular osteomyofascial flap without a skin paddle during maxillary and mandibular reconstruction. Head Neck. 2015 Apr 27. doi: 10.1002/hed.24109. [Epub ahead of print]84. Fan S, Chen WX, Lv XB, Tang QL, Sun LJ, Liu BD, Zhong JL, Lin ZY, Wang YY, Li QX, Yu X, Zhang HQ, Li YL, Wen B, Zhang Z, Chen WL, Li JS. miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1. Cancer Lett. 2015 Jul 1;362(2):183-91. doi: 10.1016/j.canlet.2015.03.045. Epub 2015 Apr 2. 83. Zhang DM, Wang YY, Liang QX, Song F, Chen WL, Zhang B.Endoscopic-Assisted Resection of Benign Tumors of the Accessory Parotid Gland. J Oral Maxillofac Surg. 2015 Aug;73(8):1499-504. doi: 10.1016/j.joms.2015.01.032. Epub 2015 Feb 7.82. Fan S, You-yuan Wang, Wei-liang Chen, et al. Synchronous reconstruction of bilateral osteoradionecrosis of the mandible using a single fibular osteocutaneous flap in nasopharyngeal carcinoma patients. Head Neck. 2015 Mar 17. doi: 10.1002/hed.24049.81. Fan S, You-yuan Wang, Wei-liang, Chen et al. Intraoral lining with the fibular osteomyofascial flap without a skin paddle during maxillary and mandibular reconstruction. Head Neck. 2015 Apr 27. doi: 10.1002/hed.24109.80. Chen WL, Xu LF, Tang QL, et al. Management of Carotid Body Tumor and Pseudoaneurysm After Blunt Dissection. J Craniofac Surg. 2015;26(2):477-480.79. Chen WL, Wang YY, Zhang DM, et al. Extended vertical lower trapezius island myocutaneous flap versus pectoralis major myocutaneous flap for reconstruction in recurrent oral and oropharyngeal cancer. Head Neck. 2014 Dec 22. doi: 10.1002/hed.23960. [Epub ahead of print]78. Zhang DM, Wang YY, Chen WL﹡, et al. Liquid nitrogen cryotherapy for lip mucous membrane venous malformation in infants. Pediatr Surg Int. 2015, 31(3):283–285.77. Lin Z, Sun L, Chen W﹡, et al.. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1.Cancer Sci. 2014 Oct;105(10):1288-98. 76. Fang SL, Wang YY, Chen WL, et al.Use of extended vertical lower trapezius island myocutaneous flaps to cover exposed reconstructive plates. J Oral Maxillofac Surg. 2014;72(10):2092.e1-7. 75. Chen WL, Wang YY, Zhang DM, et al. Endoscopy-assisted transoral resection of large benign parapharyngeal space tumors. Br J Oral Maxillofac Surg. 2014 52(10):970-973.74. Fan S, Liang FY, Chen WL﹡, et al.Minimally Invasive Selective Neck Dissection: A Prospective Study of Endoscopically Assisted Dissection via a Small Submandibular Approach in cT1-2N0 Oral Squamous Cell Carcinoma. Ann Surg Oncol. 2014;21(12):3876-81.73. Liang QX, Liang YC, Chen WL﹡, et al. RECK overexpression reduces invasive ability in ameloblastoma cells. J Oral Pathol Med. 2014;43(8):613-8.72. Zhou B, Chen WL﹡, Wang YY, et al. A role for cancer-associated fibroblasts in inducing the epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma. J Oral Pathol Med. 2014;43(8):585-92.71. Zhang DM,Chen WL﹡, Lin ZY, et al. Use of a folded reverse facial-submental artery submental island flap to reconstruct soft palate defects following cancer ablation. J Craniomaxillofac Surg. 2014;42(6):910-914.70. Chen W, Yang Z, Zhang D, et al. Second salvage surgery with extended vertical lower trapezius island myocutaneous flap reconstruction for advanced re-recurrent oral and oropharyngeal squamous cell carcinoma. Int J Oral Maxillofac Surg. 2014;43(5):531-8. 69. Wang Y, Lin Z, Chen W﹡. et al. Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma. Br J Cancer. 2014;110(3):695-705. 68. Yang ZH, Zhang DM, Chen WL﹡, et al. Reconstruction of through-and-through oral cavity defects with folded extended vertical lower trapezius island myocutaneous flap. Br J Oral Maxillo facSurg. 2013;51(8):731-5.67. Huang Z, Zhuo Y, Chen W﹡et al. The role of NEFL in cell growth and invasion in head and neck squamous cell carcinoma cell lines. J Oral Pathol Med. 2014;43(3):191-8. 66. Huang Z, Wang L, Chen W﹡, et al. Overexpression of CD147 contributes to the chemoresistance of head and neck squamous cell carcinoma cells. J Oral Pathol Med. 2013;42(7):541-6. 65. Wang L, Chen WL﹡, Chen JF, et al. Surgical excision of sialoblastoma in the parotid gland in newborn. Int J Pediatr Otorhinolaryngol. 2013;77(8):1268-71. 64. Chen WL, Wang WJ, Huang ZQ, Zhang DM. Osteotomy in the vertical ramus outside the mandibular foramen for tumours in the parapharyngeal space. J Craniomaxillofac Surg. 2014(42): e29-e32. 63. Chen WL, Zhang DM, Yang ZH, et al. Functional hemitongue reconstruction using innervated supraclavicular fasciocutaneous island flaps with the cervical plexus and reinnervated supraclavicular fasciocutaneous island flaps with neurorrhaphy of the cervical plexus and lingual nerve. Head Neck. 2014;36(1):66-70.62. Chen WL, Zhang LP, Huang ZQ, et al. Percutaneous sclerotherapy of sialoceles after parotidectomy with fibrin glue, OK-432, and bleomycin. Br J Oral Maxillofac Surg. 2013;51(8):786-8. 61. Wu H, Chen WL﹡, Yang ZH, et al. Functional Reconstruction With an Extended Supraclavicular Fasciocutaneous Island Flap Following Ablation of Advanced Oropharyngeal Cancer. J Craniofac Surg. 2012 ;23(6):1668-71. 60. You YH, Chen WL﹡, Zhang DM. Closure of large oropharyngocutaneous fistulas using a folded extensive supraclavicular fasciocutaneous island flap J Oral Maxillofac Surg Med Pathol.2013;25(4):310-31359. Wei FH, Chen WL﹡, Zhang da M. Contralateral Full-thickness Retroangular Flap for the Reconstruction of Midfacial Through-and-through Defects Following Skin Cancer Ablation. Chin J Dent Res. 2012;15(1):21-4. 58. Li JS, Chen WL﹡, Zhang DM, et al. Extracapsular dissection of pleomorphic adenoma of the parotid gland through minimal preauricular and retroauricular incisions in children. J Craniofac Surg. 2012;23(3):661-3.57. Li HG, Han JJ, Chen WL﹡, et al. IMP3 Is a Novel Biomarker to Predict Metastasis and Prognosis of Tongue Squamous Cell Carcinoma. J Craniofac Surg. 2011;22(6):2022-5.56. Chen WL, Wang YY, Zhou M, et al. Double mental neurovascular v-y island advancement flaps combined with tongue flaps for functionally reconstructing total lower-lip defects. J Craniofac Surg. 2012;23(1):181-3.55. Fan S, Tang QL, Chen WL﹡, et al. A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. Int J Oral Sci. 2011;3(4):180-91. 54. Chen WL, Yang ZH, Zhang DM, et al. Reconstruction of Major Full Cheek Defects With Combined Extensive Pedicled Supraclavicular Fasciocutaneous Island Flaps and Extended Vertical Lower Trapezius Island Myocutaneous Flaps After Ablation of Advanced Oral Cancer. J Oral Maxillofac Surg. 2012;70(5):1224-31. 53. You YH, Chen WL﹡, Huang ZQ, et al. SMAS fold flap and allograft dermal matrix repairing parotid bed following parotidectomy to prevent facial deformity and Frey's syndrome. J Oral Maxillofac Surg Oral Med Oral Pathol. 2012, 24(1):18-22. 52.Tang QL, Chen WL﹡, Tan XY, et al. Expression and significance of Cyr61 in distant metastasis cells of human primary salivary adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(2):228-36. 51.Peng GG, Chen WL﹡, Wu JW, et al. Eagle's Syndrome Treated with Dissection of the Styloid Process via an Extraoral Approach Combined with Antidepressants. Chin J Dent Res. 2011;14(1):37-40.50. Chai Q, Chen WL﹡, Huang ZQ，et al. Preliminary experiences in treating infantile hemangioma with propranolol. Ann Plast Surg. 2014;72(2):169-72. 2011 May 27. [Epub ahead of print]49. Chen WL, Zhou M, Ye JT, et al. Maxillary Functional Reconstruction Using a Reverse Facial Artery–Submental Artery Mandibular Osteomuscular Flap with Dental Implants. J Oral Maxillofac Surg.2011;69(11):2909-14.48. Tang QL, Fan S, Chen WL﹡, et al. Expression of Cyr61 in primary salivary adenoid cystic carcinoma and its relation to Ki-67 and prognosis. Oral Oncol. 2011;47(5):365-70.47. Zhen Y, Wang JG, Chen WL﹡, et al. Efficacy survey of swallowing function and quality of life in response to therapeutic intervention following rehabilitation treatment in dysphagic tongue cancer patients. Eur J Oncol Nurs. 2012;16(1):54-8.46. Wang YY, Chen WL﹡, Huang ZQ, et al. Expression of the membrane-cytoskeletal linker Ezrin in salivary gland adenoid cystic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(1):96-104.45. Chen WL, Huang ZQ, Chai Q, et al. Percutaneous sclerotherapy of massive macrocystic lymphatic malformations of the face and neck using fibrin glue with OK-432 and bleomycin. Int J Oral Maxillofac Surg. 2011;69(2):574.44. Chen WL, Huang ZQ, Yang ZH, et al. Deep Plane Cervicofacial Flap for Reconstruction of Large Oncosurgical Defects of the Cutaneous Face and Neck. Chin J Dental Research. 2009;12(1):27-30.43. Chen WL, Ye JT，Yang ZH， et al. Mandible reconstructed with mandibular osteomuscular and facial-cervico-pectoral flap. Asian J Oral Maxillofac Surg. 2011;(23):69-72 42. Chen WL, Wang YY, Zhang DM, et al. Use of the contralateral retroangular island flap for reconstructing midfacial defects after skin cancer ablation. Head Neck. 2011;33(12):1765-8.41.Wang JG, Chen WL﹡, Ye HS, et al. Reverse facial artery-submental artery deepithelialised submental island flap to reconstruct maxillary defects following cancer ablation. J Craniomaxillofac Surg. 2011;39(7):499-502.40.Huang ZQ, Chen WL﹡, Li HG, et al. Extracellular matrix metalloproteinase inducer expression in salivary gland tumors: a correlation with microvessel density. J Craniofac Surg. 2010;21(6):1855-60. 39. Chen WL, Zhang DM, Yang ZH, et al. Extended supraclavicular fasciocutaneous island flap based on the transverse cervical artery for head and neck reconstruction after cancer ablation. J Oral Maxillofac Surg. 2010;68(10):2422-30. 38.Chen WL, Chang SH, Ye ZT, et al. A pedicled mandibular osteomuscular flap for reconstructing composite mandibular defects. Oral Surg. 2010;3(1):16-21.37. Chen WL, Zhang B, Wang JG, et al. Reconstruction of large defects of the neck using an extended vertical lower trapezius island myocutaneous flap following salvage surgery for neck recurrence of oral carcinoma. J Plast Reconstr Aesthet Surg. 2011;64(3):319-22. 36. Zhang B, Wang JG, Chen WL﹡, et al. Reverse facial-submental artery island flap for reconstruction of oropharyngeal defects following middle and advanced-stage carcinoma ablation. Br J Oral Maxillofac Surg. 2011;49(3):194-7. 35. You YH, Chen WL﹡, Wang YP, et al. The feasibility of facial-submental artery island myocutaneous flaps for reconstructing defects of the oral floor following cancer ablation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(6):e12-6. 34. Chen WL, Huang ZQ, Li JS, et al. Percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin. Int J Pediatr Otorhinolaryngol. 2010;74(4):422-425. 33. Chen WL, Yang ZH, Huang ZQ, et al. Facial Contour Reconstruction After Benign Tumor Ablation Using Reverse Facial-Submental Artery Deepithelialized Submental Island Flaps. J Craniofac Surg. 2010;21(1):83-86. 32. You YH, Chen WL﹡, Wang YP, et al. Reverse facial-submental artery island flap for the reconstruction of maxillary defects after cancer ablation. J Craniofac Surg. 2009;20(6):2217-20. SCI31. Fan S,Chen WL﹡,Pan CB, et al. Anesthetic efficacy of inferior alveolar nerve block plus buccal infiltration or periodontal ligament injections with articaine in patients with irreversible pulpitis in the mandibular first molar. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(5):e89-93. 30. Chen WL, Huang ZQ, Zhang DM, et al. Percutaneous sclerotherapy of massive venous malformations of the face and neck using fibrin glue combined with OK-432 and pingyangmycin. Head Neck. 2010;32(4):467-472. 29. Li HG, Li JS, Chen WL﹡, Wang L, et al. Prognostic significance of erythropoietin and erythropoietin receptor in tongue squamous cell carcinoma. Br J Oral Maxillofac Surg. 2009;47(6):470-5. 28. Chen WL, Yang ZH, Li JS, et al. Submental flap for reconstructing tongue defect with V-Y advancement flap for repairing submental defect. Otolaryngol Head Neck Surg. 2009;141(2):202-206. 27. Chen WL, Ye JT, Xu LF, et al. A multidisciplinary approach to treating maxillofacial arteriovenous malformations in children. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(1):41-47. 26. Chen WL, Zhang B, Wang JG, et al. Surgical excision of cervicofacial giant macrocystic lymphatic malformations in infants and children. Int J Pediatr Otorhinolaryngol. 2009;73(6):833-7. 25. Yan L, Chen WL﹡, Zeng SG, et al. Inhibition of VEGF expression in tongue squamous cancer cells via RNA interference silencing of iNOS gene. Int J Oral Maxillofac Surg. 2009，38(4):369-373. 24. Li JS, Chen WL﹡, Huang ZQ, et al. Pediatric Mandibular Reconstruction After Benign Tumor Ablation Using a Vascularized Fibular Flap. J Craniofac Surg. 2009;20(2):431-434. 23. Chen WL, Chen ZW, Yang ZH, et al. The trapezius osteomyocutaneous island flap for reconstructing hemimandibular and oral defects following the ablation of advanced oral malignant tumors. J Craniomaxillofac Surg. 2009;37(2):91-95.22. Chen WL, Liu S, Li HG, et al. Transplantation of a reverse facial artery pedicled submandibular gland in a dog. Int J Oral Maxillofac Surg. 2008;37(11):1054-8. 21.Chen WL, Ye JT, Yang ZH, et al. Reverse facial artery-submental artery mandibular osteomuscular flap for the reconstruction of maxillary defects following the removal of benigntumors. Head Neck. 2009;31(6):725-731.20. Fan S, Chen WL﹡, Yang ZH, et al. Comparison of the efficiencies of permanent maxillary tooth removal performed with single buccal infiltration versus routine buccal and palatal injection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(3): 359-363. 19. Chen WL, Zhang B, Li JS, et al. Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy. Ann Plast Surg. 2009;62(2):154-7. 18. Chen WL, Fang SL. Removal of second branchial cleft cysts using a retroauricular approach. Head Neck. 2009;31(5):695-698. 17. Chen WL, Ouyang KX, Li HG, et al. Expression of Inducible Nitric Oxide Synthase and Vascular Endothelial Growth Factor in Ameloblastoma. J Craniofac Surg. 2009;20(1):171-175. 16. Chen WL, Fang S, Wang K, et al. Reconstruction with Extended Vertical Lower Trapezius Island Myocutaneous Flap for Total Glossectomy. Chin J Dental Research.2008;11(1):42-46.15. Chen WL, Yang ZH, Wang YJ, et al. Removal of the submandibular gland using a combined retroauricular and transoral approach. J Oral Maxillofac Surg. 2009;67(3):522-7. 14. Chen W, Li J, Yang Z, et al. SMAS fold flap and ADM repair of the parotid bed following removal of parotid haemangiomas via pre- and retroauricular incisions to improve cosmetic outcome and prevent Frey's syndrome. J Plast Reconstr Aesthet Surg. 2008;61(8):893-898. 13. Chen WL, Yang L, Zeng SG, et al. Effect of using RNA interference to alter iNOS gene expression on the proliferation of tongue squamous cell carcinoma cell line Tca8113. Br J Oral Maxillofac Surg. 2008,46(6):435-438.12. Chen WL, Feng HJ, Li HG. Expression and significance of hypoxemia-inducible factor-1alpha in osteosarcoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106(2):254-257. 11. Chen WL, Yang ZH, Li JS, et al. Reconstruction of the tongue using an extended vertical lower trapezius island myocutaneous flap after removal of advanced tongue cancer. Br J Oral Maxillofac Surg. 2008，46(5):379-382. 10. Chen WL, Li JS, Yang ZH, et al. Two submental island flaps for reconstructing oral and maxillofacial defects following cancer ablation. J Oral Maxillofac Surg. 2008;66(6):1145-56. 9. Chen WL，Li JS, Yang ZH， et al. Extended vertical lower trapezius island myocutaneous flap for repairing extensive oropharyngeal defects. J Oral Maxillofac Surg. 2009;67(6):1349-53. 8. Chen WL, Yang ZH, Bai ZB, et al. A pilot study on combination compartmentalization and sclerotherapy for the treatment of massive venous malformations of the face and neck. J Plast Reconstr Aesthet Surg. 2008;61(12):1486-92.7. Chen WL, Chen ZW, Yang ZH, et al. Pedicled Mandibular Osteomuscular Flap for Zygomatic Reconstruction through a Modified Weber-Ferguson Incision. J Craniofac Surg. 2008; 19(1):235-240. 6. Chen WL, Feng HJ, Li JS, et al. Expression and pathological relevance of inducible nitric oxide synthase in osteosarcoma of the jaws. Int J Oral Maxillofac Surg. 2007;36(6):541-4. 5. Chen WL, Li J, Yang Z, et al. Extended vertical lower trapezius island myocutaneous flap in reconstruction of oral and maxillofacial defects after salvage surgery for recurrent oral carcinoma. J Oral Maxillofac Surg. 2007;65(2):205-11. 4. Chen W, Zeng S, Li J, et al. Reconstruction of full cheek defects with combined temporalis myofacial flaps and facial-cervico-pectroral flaps. Oral Surg Oral Med, Oral Pathol Oral Radiol Endod. 2007;103(1): e10-e15. 3. Chen WL, Deng YF, Peng GG, Li JS, et al. Extended vertical lower trapezius lsland myocutaneous flap for reconstruction of cranio-maxillofacial defects. Int J Oral Maxillofac Surg. 2007;36(2):165-70. 2. Chen WL, Li JS, Yang ZH, et al. Recurrent ameloblastoma of the anterior skull base: three cases treated by radical resections. J Craniomaxillofac Surg. 2006;34(7):412-4. 1. Chen W, Wang J, Li J, et al. Comprehensive treatment of arteriovenous malformations in the oral and maxillofacial region. J Oral Maxillofac Surg. 2005;63(10):1484-1488.